Cambridge Education

The BIOFIRE System and Your Immune System

The BIOFIRE System provides syndromic infectious disease testing, empowering healthcare providers to select the most appropriate test, the first time. Patients benefit from faster diagnoses and more targeted treatment. Clinicians benefit from improved antibiotic stewardship. Labs save money and gain efficiency.

The BioFire Pneumonia Plus Panel (PN panel) tests native sputum (including mini-BAL) and endotracheal lavage and bronchoalveolar slurries (including mini BAL) for 33 clinically important pathogens and resistance genes to antimicrobials within one hour.

Respiratory

The burning of biomass (wood plants, agro-forestry and other organic materials) produces gaseous pollutants as well as fine particles of matter that negatively impact the respiratory system. Additionally, the environmental issues caused by forest fires like droughts, could be potentiated by climate change, increasing their negative impact on the health of humans.

In the United States wildfire smoke is associated with hospitalizations for respiratory diseases like asthma, COPD, and lung cancer. Furthermore, this type of air pollution is an important risk factor for cardiovascular disease and a major contributor to the burden of illness in the most vulnerable populations that include those who are of lower socioeconomic status (SES).

In the COVID-19 pandemic, many communities were exposed to unhealthy levels of air pollution resulting from wildfires. The public health response has been limited to a communications campaign about symptom management. This knowledge gap is alarming due to the fact that smoking cigarettes and other causes of air pollution can cause health problems.

Researchers are now evaluating the best way to safeguard public's health during future events of this kind. NIH is funding research on this important public health issue through the BLUE CORAL study and its successor bio ethanol fire CORAL.

For the first time, a prospective cohort study will evaluate long-term effects of exposure to smoke from wildfires as well as other sources. FIRE CORAL is looking for adult participants hospitalized for COVID-19's index episode who speak English or Spanish and are not pregnant. The bio ethanol fire basket CORAL protocol includes a battery of tests conducted in-person, objectively measuring pulmonary function testing and lung imaging and functional assessment.

Smoke and other particles can cause or worsen chronic respiratory conditions like emphysema COPD, and pneumonia. A variety of steps can be taken to prevent or minimize the negative health effects of exposure to smoke, including avoiding outdoor activities when feasible and wearing the EPA's "N95" mask that is designed to catch fine particles.

Smoking can also cause irritation to the throat, eyes and nose. To reduce the symptoms, the lungs should be flushed by drinking lots of water and taking medicines that reduce inflammation, such as corticosteroids.

Bloodstream

The bloodstream is the first line of defense against germs that invade your system. Dendritic cells are specialized cells that are like the fire department's call center. they take antigens (molecules that trigger an immune response) from germs that are invading your body and then release proteins that signal other white blood cells to fight them. The total number of white blood cells, differentials and band cells increased after firefighters' firefighting tasks as compared to levels following strenuous exercise without fire-fighting.

Skin

Dermatologists were concerned about the smoke and ash that resulted from the California wildfires could have negative effects on the skin of those who were exposed to them. Maria Wei is a graduate student from University of California, Irvine. She examines how extreme wildfire pollution affects the skin. Her research was published in Scientific Reports on April 22.

The research of Wei shows that the temperature of a person's skin varies based on how long the body is exposed to flames. It could take up to two hours for the skin of a person to reach its "flash point"--the moment at which it starts to burn and then turn into ash. That's why it's important to avoid being near a bioethanol biofuel fire bowl (Suggested Looking at) or campfire, and why you should wear protective clothing if you are outdoors in the midst of a forest bio ethanol fire basket or even just the heat of the day.

While it's essential to take precautions against wildfire pollution, there is no way to stop forest fires from happening. Wei believes that as climate change causes forests to burn faster, the number of people who suffer from wildfires will increase. This means that more people will have to wear caps and long sleeves and thick moisturizers.

The air pollution from wildfires can cause atopic dermatitis to the skin, which is a condition that causes itchy skin in many people. It is believed that this is because the particles in smoke can block pores, which makes the atopic dermatitis condition worse.

Another issue is that atopic dermatitis tends to make people more sensitive to UV light, which can also be aggravated by smoke from wildfires. This can lead to people looking for tanning salons and get tanned with less protection.

A treatment using ice and fire could help to reduce atopic symptoms of dermatitis, but it is not recommended for anyone with an open wound or rash. This treatment is not recommended for those who have active acne, or if you're pregnant or nursing. The IS Clinical bio fire & Ice Facial located at Novuskin Las Vegas' premier membership MedSpa is a result-driven, intensive facial that bridges between an easy facelift and a peel, but without the need for downtime. It's designed to rejuvenate skin, reduce rosacea, reduce fine lines and acne scarring, as well as stimulate cellular regeneration. It's a fantastic treatment that will give you an energizing glow.

Infections

The human body is a complex system of organs and tissues that work to shield us from infections. Infections are caused by microscopic microorganisms like viruses, bacteria, parasites and fungi that infect healthy cells and cause them to replicate out of control. If this occurs your immune system could react with symptoms of illness. These symptoms could range from a swollen or achy nose to stomach ache and can include a fever high or swollen glands. You may also experience a skin rash. The type of infection and its location can affect the severity of your symptoms.

Infections can spread in a variety of ways, but the most common are spread from person to by droppings that hang in the air after sneezing or coughing. This is how bacterial illnesses like strep, tuberculosis and meningococcal disease, as well as viral infections like the common cold and influenza spread. Certain infections caused by bacteria, such as skin infections and sexually transmitted diseases (STIs) like gonorrhea or chlamydia are transmitted by direct contact with infected tissue or mucous membranes, or through indirect contact with surfaces that are contaminated. Some bacterial diseases are transmitted by insects such as mosquitoes, ticks or fleas and can be spread by bites from these bugs you.

The virus and the parasites are small enough to penetrate your bloodstream and infect your cells which can lead to serious diseases such as the common cold and AIDS. Fungi can cause skin problems such as ringworm and athlete's foot and others can infect the respiratory system and the nervous system.

The BioFire Panel employs our revolutionary FilmArray Technology to test the bronchoalveolar and sputum samples for a comprehensive listing of pathogens involved in upper respiratory infection. The kit comes with a reagent bag that contains all the chemistry necessary to perform reverse transcription as well as nested multiplex PCR detection in one machine. This is a simple solution that helps clinicians identify and treat patients with several respiratory symptoms. This test has been granted an Emergency Use Authorization and is available through bioMerieux's CLIA moderate and high complexity labs.