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Θεσσαλονίκη Η κλινική δοκιμή του φαρμάκου διήρκεσε 52 εβδομάδες και έγινε σε 1.104 ασθενείς, Βόλος Θεσσαλονίκη: Κατασκευη eshop Θεσσαλονίκη Το κάστρο του Βόλου οι οποίοι συνέχισαν να παίρνουν τις στατίνες τους..."

Πειραματικό φάρμακο μείωσε κατά 52% την «κακή» χοληστερόλη μέσα σε ένα χρόνο Θεσσαλονίκη

Η κλινική δοκιμή του φαρμάκου διήρκεσε 52 εβδομάδες και έγινε σε 1.104 ασθενείς, οι οποίοι συνέχισαν να παίρνουν τις στατίνες τους

Ένα πειραματικό φάρμακο κατάφερε να μειώσει στο μισό (κατά 52%) το επίπεδο της «κακής» χολητσερόλης (LDL) μέσα σε διάστημα ενός χρόνου, χωρίς μάλιστα να εμφανιστούν σοβαρές παρενέργειες στους περισσότερους ασθενείς.

Το φάρμακο με την ονομασία evolocumab, που ανήκει στην πολλά υποσχόμενη κατηγορία των λεγόμενων «αναστολέων PCSK9», τα οποία αποτελούν μια εναλλακτική ή συμπληρωματική λύση σε σχέση με τις ευρέως σήμερα χρησιμοποιούμενες στατίνες, αναπτύχθηκε από την αμερικανική φαρμακευτική και βιοτεχνολογική εταιρία Amgen, σύμφωνα με το πρακτορείο Ρόιτερ.

Η κλινική δοκιμή του φαρμάκου διήρκεσε 52 εβδομάδες και έγινε σε 1.104 ασθενείς, οι οποίοι συνέχισαν να παίρνουν τις στατίνες τους. Κάθε ασθενής ελάμβανε 420 μιλιγκράμ του νέου ενέσιμου φαρμάκου μια μόνο φορά το μήνα.

Μετά το τέλος της δοκιμής, το επίπεδο της «λιποπρωτεΐνης χαμηλής πυκνότητας» (LDL) είχε υποχωρήσει κατά 52% και η μείωση αυτή ήταν πρόσθετη σε σχέση με την μείωση που οι στατίνες επέφεραν. Επίσης τα επίπεδα άλλων λιπιδίων (τριγλυκεριδίων) μειώθηκαν κατά 9%, ενώ η «καλή» χοληστερόλη (HDL) αυξήθηκε κατά 9%.

Η νέα κατηγορία φαρμάκων (αναστολέων PCSK9) θεωρούνται εν δυνάμει η μεγαλύτερη πρόοδος στο πεδίο καταπολέμησης της χοληστερόλης εδώ και πολλά χρόνια. Ήδη αρκετές φαρμακευτικές εταιρίες αναπτύσσουν τέτοια φάρμακα, τα οποία μπλοκάρουν τη δράση μιας πρωτεΐνης που εμποδίζει το ήπαρ να απομακρύνει την «κακή» χοληστερόλη από το αίμα. Εκτός της Amgen, η Pfizer και οι συνεργαζόμενες Regeneron - Sanofi βρίσκονται σε προχωρημένο στάδιο κλινικών δοκιμών για τέτοιους αναστολείς της πρωτεΐνης PCSK9.

Τα νέου τύπου φάρμακα είναι πιθανότερο να χρησιμοποιηθούν πρωτίστως σε ασθενείς που δεν ανέχονται καλά τις στατίνες και σε όσους συνεχίζουν να έχουν πολύ υψηλή LDL παρά τη θεραπεία τους με ισχυρές στατίνες.

«Τα αποτελέσματα της μελέτης είναι ενθαρρυντικά, καθώς το evolocumab μπορεί να αποτελέσει μια δυνητική θεραπευτική επιλογή για τους ασθενείς που δεν μπορούν να ελέγξουν τα επίπεδα της χοληστερόλης τους» δήλωσε ο επικεφαλής της κλινικής δοκιμής δρ Μάικλ Κόρεν του Κέντρου Κλινικών Ερευνών Τζάκσονβιλ της Φλόριντα.

Σοβαρές παρενέργειες εμφανίστηκαν στο 7,1% των ασθενών έναντι 6,3% όσων έπαιρναν μόνο στατίνες. Η αύξηση των επιπέδων των ενζύμων στο ήπαρ παρουσιάστηκε στο 1,8% των ασθενών έναντι 1,6% σε όσους έπαιρναν μόνο στατίνες. Όπως είπε ο Μάικλ Κόρεν, «το φάρμακο τα πήγε θαυμάσια από άποψη Ασφάλειας», πράγμα που πιθανώς ανοίγει το δρόμο για την έγκρισή του από την αρμόδια εποπτική Αρχή των ΗΠΑ (την FDA).

Θεσσαλονίκη Νέο «τσεκούρι» στις συντάξεις

Αίσθηση από την παραδοχή της διοίκησης του ΙΚΑ ότι έγιναν λάθος υπολογισμοί στις περικοπές χιλιάδων συντάξεων - Κατόπιν εορτής, το Ίδρυμα ανακοίνωσε ότι θα προχωρήσει σε επανέλεγχο και αποκατάσταση των αδικιών

Σε μειώσεις συντάξεων και παροχών θα οδηγηθούν άμεσα τα ασφαλιστικά ταμεία, εξαιτίας της δεινής οικονομικής κατάστασης στην οποία έχουν περιέλθει, λόγω της υστέρησης εσόδων, της ύφεσης και της ανεργίας.

Σύμφωνα με την εκτίμηση του προέδρου της ομοσπονδίας των εργαζομένων στα ασφαλιστικά ταμεία, η κύρια σύνταξη θα υποστεί μείωση 10%, η επικουρική 30%, ενώ θα καταργηθεί εντελώς το εφάπαξ.

Οι εργαζόμενοι της υπηρεσίας στο υπουργείο Εργασίας (ασφαλιστικά ταμεία, ΟΑΕΔ κλπ) εξήγγειλαν επαναλαμβανόμενες πενθήμερες απεργίες, αρχής γενομένης από τις 16 Σεπ Τεμβρίου, διαμαρτυρόμενοι Βελτιστοποίηση για Μηχανές Αναζήτησης (SEO) Θεσσαλονίκη τη διαθεσιμότητα 600 συναδέλφων τους.

«Δεν περισσεύει κανένας, αν αποχωρήσουν κι άλλοι υπάλληλοι» τόνισε ο πρόεδρος των εργαζομένων του ΙΚΑ, Γιώργος Κυριακόπουλος.

Και συμπλήρωσε: «Θα κάνουν διπλάσιο χρόνο να εκδοθούν οι κύριες συντάξεις. Ήδη, η καθυστέρηση φτάνει τους 15 μήνες, ενώ σε κάποια υποκαταστήματα της περιφέρειας, όπως της Χαλκίδας, φτάνουν τους 24».

Σύμφωνα με τους συνδικαλιστές του ΟΑΕΔ, οι εγγεγραμμένοι άνεργοι έχουν ξεπεράσει το 1.000.000. Κάτι το οποίο αποφεύγει να δημοσιοποιήσει ο Οργανισμός, καθώς δεν έχει ανακοινώσει τα στοιχεία για την ανεργία εδώ και τέσσερις μήνες, όπως αναφέρει το newmoney.gr.

«Κούρεψαν» κατά λάθος χιλιάδες συντάξεις

Εν τω μεταξύ, αίσθηση προκαλεί η παραδοχή, εκ μέρους της ηγεσίας του ΙΚΑ, ότι έγιναν λάθος υπολογισμοί στις περικοπές χιλιάδων συντάξεων.

Σύμφωνα με τον «Ελεύθερο Τύπο», η παραδοχή των λανθασμένων υπολογισμών έγινε μάλιστα από τον ίδιο το διοικητή του Ιδρύματος, Ροβέρτο Σπυρόπουλο, ο οποίος απέσ ΤΕΙλε χθες σχετικό έγγραφο προς τις αρμόδιες υπηρεσίες, τις οποίες και καλεί να σταματήσουν να διορθώνουν τα λάθη στις μειώσεις των συντάξεων που εντοπίζουν οι ίδιοι οι συνταξιούχοι, πηγαίνοντας στα υποκαταστήματα, καθώς στο εξής, όπως αναφέρει, η διαδικασία αυτή θα γίνει μαζικά για όλες τις συντάξεις όλων των Ταμείων κι εκεί θα φανεί αυτόματα πόσοι είχαν μεγαλύτερες μειώσεις από αυτές που δικαιολογούν οι μνημονιακοί νόμοι, οπότε και θα πρέπει να τους επιστραφούν τα ποσά, αλλά και πόσοι γλίτωσαν τις περικοπές, επειδή τα Ταμεία τους δεν είχαν αποστείλει τα ακριβή στοιχεία στο Ενιαίο Σύστημα Πληρωμής Συντάξεων της ΗΔΙΚΑ. Διαβάστε περισσότερα εδώ

Πλέον, κατόπιν... εορτής, το ΙΚΑ προχωρά σε επανέλεγχο των περικοπών στα ποσά των συντάξεων, έπειτα από τη διαπίστωση ότι υπήρξαν περιπτώσεις κατά τις οποίες παρακρατήθηκαν μεγαλύτερα ποσά και άλλες, όπου δεν έγιναν οι μειώσεις που είχαν προβλεφθεί.

Τα λάθη που έγιναν στη διαδικασία προσαρμογής των συντάξεων, είχαν σαν αποτέλεσμα να μην περικοπούν κατά 12% όλες οι συντάξεις άνω των 1.300 ευρώ, ενώ σε άλλες περιπτώσεις έγιναν μειώσεις αδίκως.

Κατά το επόμενο χρονικό διάστημα, το ΙΚΑ θα καταγράψει αναλυτικά σε ποιους πρέπει να επιστραφούν ποσά που έχουν παρακρατηθεί και σε ποιους πρέπει να επιβληθούν μειώσεις. Διαβάστε περισσότερα εδώ

Θεσσαλονίκη Ασία: Ένας στους τέσσερις άνδρες παραδέχεται ότι είναι βιαστής!

Στην Παπούα Νέα Γουινέα, περίπου το 62% των ερωτηθέντων παραδέχτηκαν ότι έχουν συνευρεθεί ερωτικά με γυναίκα χωρίς την συγκατάθεσή της...

Το ένα τέταρτο των Ασιατών παραδέχεται ότι έχει βιάσει γυναίκα, σύμφωνα με έρευνα των Ηνωμένων Εθνών που πραγματοποιήθηκε σε έξι χώρες της περιοχής και δόθηκε σήμερα στη δημοσιότητα.

Στην Παπούα Νέα Γουινέα, περίπου το 62% των ερωτηθέντων παραδέχτηκαν ότι έχουν συνευρεθεί ερωτικά με γυναίκα χωρίς την συγκατάθεσή της, σύμφωνα με την έρευνα του ΟΗΕ.

"Τα συμπεράσματα της έκθεσης επιβεβαιώνουν την ύπαρξη της βίας κατά των γυναικών στην περιοχή. Και η βία είναι απολύτως συνδεδεμένη με την ανισότητα μεταξύ των δύο φύλων", δήλωσε η Έμα Φούλου, εκ των επικεφαλής της έρευνας.

Η έκθεση με τίτλο "Γιατί Ορισμένοι Άνδρες Χρησιμοποιούν Βία Κατά των Γυναικών και Πώς Μπορούμε να το Αποφύγουμε;" βασίστηκε σε συνεντεύξεις που δόθηκαν κατά το διάστημα 2010-2013 από 10.000 άνδρες και 3.000 γυναίκες στο Μπανγκλαντές, την Καμπότζη, την Κίνα, την Ινδονησία, την Σρι Λάνκα και την Παπούα Νέα Γουινέα.

Η έκθεση παρείχε λεπτομερή στοιχεία για την βία που ασκούν οι άνδρες εις βάρος των γυναικών και τα κίνητρά τους.

Η περιοχή της Ασίας-Ειρηνικού επιλέχτηκε για την πρώτη τέτοια έκθεση κυρίως επειδή τα Ηνωμένα Έθνη διαθέτουν πολλά ενεργά προγράμματα για την αντιμετώπιση της βίας κατά των γυναικών στην Ασία.

Από την έρευνα προέκυψε ότι το ποσοστό σωματικής και σεξουαλικής βίας εις βάρος συζύγων και συντρόφων είναι υψηλό, καθώς στην Ινδονησία, για παράδειγμα, κυμαίνεται στο 26%, ενώ στην Παπούα Νέα Γουινέα στο 80%.

Μεταξύ των βιαστών που παραδέχονται την πράξη τους, το πιο κοινό κίνητρο που επικαλούνται είναι η αίσθηση σεξουαλικής κυριότητας.

"Παρότι το αλκοόλ συχνά θεωρείται ότι είναι ένας κοινός παράγοντας διάπραξης βίαιου εγκλήματος, ήταν η λιγότερο κοινή απάντηση που έδωσαν οι ερωτηθέντες", σύμφωνα με την έρευνα.

Η έρευνα αποπειράθηκε επίσης να εξετάσει το θέμα του βιασμού με θύματα άνδρες.

Στο Μπανγκλαντές, την Κίνα και την Ινδονησία, περίπου το 2% των ερωτηθέντων παραδέχτηκαν ότι έχουν βιάσει άλλον άνδρα, ενώ στη Σρι Λάνκα και την Καμπότζη το ποσοστό ανέρχεται, κατά μέσον όρο, σε 3% με 4% και στην Παπούα Νέα Γουιένα σε 8%.

Όπως προκύπ ΤΕΙ, η Παπούα Νέα Γουινέα έχει σχετικά χαμηλό επίπεδο ισότητας των δύο φύλων, έλλειψη νομοθεσίας κατά του βιασμού, ενώ οι πρόσφατες συγκρούσεις έχουν οδηγήσει στην αποδοχή της βίας, εξηγεί η Φούλου.

Η έκθεση διαπίστωσε ότι περίπου το 72% με 97% των ανδρών που παραδέχτηκαν ότι έχουν βιάσει δεν αντιμετώπισαν τις συνέπειες του νόμου.

Θεσσαλονίκη

source: http://www.protothema.gr/ugeia/article/329900/peiramatiko-farmako-meiose-kata-52-tin-kaki-holisteroli-mesa-se-ena-hrono-/

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Online gambling has skilled a significant increase in popularity recently, with different casino games attracting players blog post from Pokertube around the planet. One such preferred online game is internet based roulette, that provides a thrilling and immersive gambling experience. This report is designed to explore the field of online roulette, speaking about its origins, game play, pros and cons, plus the future prospects of the virtual casino online game.

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